N-乙醯轉移酶2
| N-乙醯轉移酶2 （芳香胺N-乙醯轉移酶） N-acetyltransferase 2 (arylamine N-acetyltransferase) | |||||||||||||
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 PDB rendering based on 2pfr. | |||||||||||||
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| 標識 | |||||||||||||
| 代號 | NAT2; AAC2; NAT-2; PNAT | ||||||||||||
| 擴展標識 | 遺傳學：612182 鼠基因：97279 同源基因：115468 ChEMBL: 2194 GeneCards: NAT2 Gene | ||||||||||||
| EC編號 | 2.3.1.5 | ||||||||||||
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| RNA表達模式 | |||||||||||||
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| 更多表達數據 | |||||||||||||
| 直系同源體 | |||||||||||||
| 物種 | 人類 | 小鼠 | |||||||||||
| Entrez | 10 | 17960 | |||||||||||
| Ensembl | ENSG00000156006 | ENSMUSG00000025588 | |||||||||||
| UniProt | P11245 | P50294 | |||||||||||
| mRNA序列 | NM_000015 | NM_008673 | |||||||||||
| 蛋白序列 | NP_000006 | NP_032699 | |||||||||||
| 基因位置 |
Chr 8: 18.25 – 18.26 Mb |
Chr 8: 67.49 – 67.49 Mb | |||||||||||
| PubMed查詢 | [1] | [2] | |||||||||||
N-乙醯轉移酶2（英語：N-acetyltransferase 2，又稱為芳香胺N-乙醯轉移酶（arylamine N-acetyltransferase），縮寫為NAT2）, 是一個由人類基因 NAT2編碼的酶[1]。
功能
[編輯]NAT2是N-乙醯基轉移酶的一種，另一種芳香胺N-乙醯轉移酶：N-乙醯轉移酶1（NAT1）的基因也在八號染色體上，位於NAT2基因附近[2]。
參考文獻
[編輯]- ^ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV. Nomenclature for N-acetyltransferases. Pharmacogenetics. February 1995, 5 (1): 1–17. PMID 7773298. doi:10.1097/00008571-199502000-00001.
- ^ Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase). （原始內容存檔於2019-10-18）.
延伸閱讀
[編輯]- Vatsis KP, Weber WW, Bell DA; et al. Nomenclature for N-acetyltransferases.. Pharmacogenetics. 1995, 5 (1): 1–17. PMID 7773298. doi:10.1097/00008571-199502000-00001.
- Windmill KF, McKinnon RA, Zhu X; et al. The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.. Mutat. Res. 1997, 376 (1-2): 153–60. PMID 9202751. doi:10.1016/S0027-5107(97)00038-9.
- Lan Q, Rothman N, Chow WH; et al. No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.. Cancer Epidemiol. Biomarkers Prev. 2003, 12 (4): 384–6. PMID 12692115.
- Ochs-Balcom HM, Wiesner G, Elston RC. A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.. Am. J. Epidemiol. 2007, 166 (3): 246–54. PMID 17535831. doi:10.1093/aje/kwm066.
- Sanderson S, Salanti G, Higgins J. Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.. Am. J. Epidemiol. 2007, 166 (7): 741–51. PMID 17675654. doi:10.1093/aje/kwm167.
外部連結
[編輯]