福瑪拉諾

福瑪拉諾
識別資訊
	IUPAC命名法 (1S,5S)-5-(hydroxymethyl)-1-methoxy-6-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-one; ;
CAS號	912569-37-0
PubChem CID	44416119;
化學資訊
化學式	C16H24O4
摩爾質量	280.36 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CC(=CC[C@@H]1[C@@](O1)(C)C2[C@]3([C@@]2(C(=O)CC3)OC)CO)C;
	InChI InChI=1S/C16H24O4/c1-10(2)5-6-12-14(3,20-12)13-15(9-17)8-7-11(18)16(13,15)19-4/h5,12-13,17H,6-9H2,1-4H3/t12-,13?,14+,15-,16+/m1/s1; Key:CANZHCRPLGNWCR-LMINUHAASA-N;

福瑪拉諾（英語：Fumarranol）是一種有機化合物，分子式C₁₆H₂₄O₄，最初作為抗血管新生藥物開發^[1]，後來發現對N-末端甲硫氨酸酶 METAP2有抑制作用，可能用於治療瘧疾^[2]^[3]。

參考文獻

^ Lu J, Chong CR, Hu X, Liu JO. Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo. Journal of Medicinal Chemistry. September 2006, 49 (19): 5645–8. PMID 16970390. doi:10.1021/jm060559v.
^ Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chemistry & Biology. February 2009, 16 (2): 193–202. PMID 19246010. doi:10.1016/j.chembiol.2009.01.006.
^ Deu E. Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation. The FEBS Journal. August 2017, 284 (16): 2604–2628. PMC 5575534 . PMID 28599096. doi:10.1111/febs.14130.