UR-144

UR-144
临床资料
商品名（英语：Drug nomenclature）	different brandnames, typical example: "TMCP-018", "KM-X1", "UR-144", "MN-001", "YX-17"
法律规范状态
法律规范	加：Schedule II; 德：Anlage II; NZ：Temporary Class; 英：Class B; 美：附表I;
识别信息
	IUPAC命名法 (1-pentylindol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone; ;
CAS号	1199943-44-6
PubChem CID	44626619;
ChemSpider	24634882 ;
UNII	1TYA7HVP1B;
KEGG	C22781 ;
ChEMBL	ChEMBL571773 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID60152635 ;
化学信息
化学式	C21H29NO
摩尔质量	311.47 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3C(C3(C)C)(C)C;
	InChI InChI=1S/C21H29NO/c1-6-7-10-13-22-14-16(15-11-8-9-12-17(15)22)18(23)19-20(2,3)21(19,4)5/h8-9,11-12,14,19H,6-7,10,13H2,1-5H3 ; Key:NBMMIBNZVQFQEO-UHFFFAOYSA-N ;

UR-144（也称TMCP-018，KM-X1，MN-001，YX-17）是一种含氮有机化合物，分子式C₂₁H₂₉NO，由美国雅培公司开发^[2]，可作为大麻素受体2的完全激动剂。

参考文献

Poso A, Huffman JW. Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands. British Journal of Pharmacology. January 2008, 153 (2): 335–346. PMC 2219524 . PMID 17982473. doi:10.1038/sj.bjp.0707567.
Chin CL, Tovcimak AE, Hradil VP, Seifert TR, Hollingsworth PR, Chandran P, et al. Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI. British Journal of Pharmacology. January 2008, 153 (2): 367–379. PMC 2219521 . PMID 17965748. doi:10.1038/sj.bjp.0707506.
Frost JM, Dart MJ, Tietje KR, Garrison TR, Grayson GK, Daza AV, et al. Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity. Journal of Medicinal Chemistry. March 2008, 51 (6): 1904–1912. PMID 18311894. doi:10.1021/jm7011613.