3-氯氧杂环丁烷

3-氯氧杂环丁烷
别名	3-氯𫫇丁环
识别
CAS号	4741-80-4
性质
化学式	C3H5ClO
摩尔质量	92.52 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

3-氯氧杂环丁烷是一种有机化合物，化学式为C₃H₅ClO。它可由3-羟基氧杂环丁烷和氯化亚砜反应得到，其副产物为1,3-二氯丙醇和3-氯丙二醇-1,2-亚硫酸酯。它和无水氯化氢反应，可以得到2,3-二氯丙醇。^[1]它在碳酸钾存在下和3-[1-(4-溴苯基)-1,2-二甲基丙基]-5-(1H-吡唑-4-基)-1,2,4-𫫇二唑在DMF中加热反应，可以得到3-[1-(4-溴苯基)-1,2-二甲基丙基]-5-[1-(3-氧杂环丁基)-1H-吡唑-4-基]-1,2,4-𫫇二唑。^[2]

参考文献

^ J. A. Wojtowicz, R. J. Polak. 3-Substituted oxetanes. The Journal of Organic Chemistry. 1973-06, 38 (11): 2061–2066 [2023-03-11]. ISSN 0022-3263. doi:10.1021/jo00951a020 （英语）.
^ Bartolozzi, Alessandra; Bosanac, Todd; Chen, Zhidong; De Lombaert, Stephane; Huber, John; Lo, Ho Yin; Loke, Pui Leng; Liu, Weimin; Morwick, Tina Marie; Olague, Alan; Riether, Doris; Tye, Heather; Wu, Lifen; Zindell, Renee. Preparation of oxadiazole derivatives for use as leukotriene production inhibitors. 2012. WO 2012024150 A1.

[1] J. A. Wojtowicz, R. J. Polak. 3-Substituted oxetanes. The Journal of Organic Chemistry. 1973-06, 38 (11): 2061–2066 [2023-03-11]. ISSN 0022-3263. doi:10.1021/jo00951a020 （英语）.

[2] Bartolozzi, Alessandra; Bosanac, Todd; Chen, Zhidong; De Lombaert, Stephane; Huber, John; Lo, Ho Yin; Loke, Pui Leng; Liu, Weimin; Morwick, Tina Marie; Olague, Alan; Riether, Doris; Tye, Heather; Wu, Lifen; Zindell, Renee. Preparation of oxadiazole derivatives for use as leukotriene production inhibitors. 2012. WO 2012024150 A1.

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