3-羥酰輔酶A脫氫酶

3-羥酰輔酶A脫氫酶
3-羥酰輔酶A脫氫酶的結構（PDB 3had）
命名 系統命名 (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase 縮寫 別名 β-hydroxyacyl dehydrogenase; β-keto-reductase; 3-keto reductase; 3-hydroxyacyl coenzyme A dehydrogenase; β-hydroxyacyl-coenzyme A synthetase; β-hydroxyacylcoenzyme A dehydrogenase; β-hydroxybutyrylcoenzyme A dehydrogenase; 3-hydroxyacetyl-coenzyme A dehydrogenase; L-3-hydroxyacyl coenzyme A dehydrogenase; L-3-hydroxyacyl CoA dehydrogenase; β-hydroxyacyl CoA dehydrogenase; 3β-hydroxyacyl coenzyme A dehydrogenase; 3-hydroxybutyryl-CoA dehydrogenase; β-ketoacyl-CoA reductase; β-hydroxy acid dehydrogenase; 3-L-hydroxyacyl-CoA dehydrogenase; 3-hydroxyisobutyryl-CoA dehydrogenase; 1-specific DPN-linked β-hydroxybutyric dehydrogenase
識別碼
EC編號	1.1.1.35
CAS號	9028-40-4
數據庫
IntEnz	IntEnz瀏覽
BRENDA	BRENDA入口
ExPASy	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc	代謝路徑
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本體	AmiGO / EGO
搜索 PMC 相關文獻 PubMed 相關文獻

3-羥酰輔酶A脫氫酶（英語：3-hydroxyacyl-CoA dehydrogenase，EC 1.1.1.35（頁面存檔備份，存於網際網路檔案館））是一種以NAD⁺或NADP⁺為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應：

(S)-3-羥酰輔酶A + NAD⁺ $\rightleftharpoons$ 3-氧酰輔酶A + NADH + H⁺

3-羥酰輔酶A脫氫酶主要參與脂肪酸的代謝過程，如β-氧化的第三步等。

參考文獻

• Hillmer P and Gottschalk G. Solubilization and partial characterisation of particulate dehydrogenases from Clostridium kluyveri. Biochim. Biophys. Acta. 1974, 334: 12–23. 
• Lehninger AL, Greville GD. The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate. Biochim. Biophys. Acta. 1953, 12 (1-2): 188–202. PMID 13115428. doi:10.1016/0006-3002(53)90138-3. * Stern JR. Crystalline beta-hydroxybutyryl dehydrogenase from pig heart. Biochim. Biophys. Acta. November 1957, 26 (2): 448–9. PMID 13499396. doi:10.1016/0006-3002(57)90040-9. 
• Wakil SJ, Green DE, Mii S and Mahler HR. Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase. J. Biol. Chem. April 1954, 207 (2): 631–8. PMID 13163047.