HaCaT細胞
HaCaT是一種來自於成年人類的永生化角質形成細胞的細胞系[1][2]。HaCaT細胞因具有良好的體外分化和增殖能力而被利用於多項研究[3][4]，作為可重現的模型來表徵人類角質形成細胞，並且解決培養壽命短和細胞系間出現變異等的問題。HaCaT細胞可以表徵多個過程，例如將它們用作皮膚中維生素D3進行代謝的模型系統[5]。
參考資料
[编辑]- ^ Boukamp, P; Petrussevska, RT; Breitkreutz, D; Hornung, J; Markham, A; Fusenig, NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.. The Journal of cell biology. 1988-03, 106 (3): 761–71 [2019-11-28]. PMID 2450098. doi:10.1083/jcb.106.3.761.
- ^ Olschläger, V; Schrader, A; Hockertz, S. Comparison of primary human fibroblasts and keratinocytes with immortalized cell lines regarding their sensitivity to sodium dodecyl sulfate in a neutral red uptake cytotoxicity assay.. Arzneimittel-Forschung. 2009, 59 (3): 146–52 [2019-11-28]. PMID 19402346. doi:10.1055/s-0031-1296378.
- ^ Schoop, VM; Mirancea, N; Fusenig, NE. Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts.. The Journal of investigative dermatology. 1999-03, 112 (3): 343–53 [2019-11-28]. PMID 10084313. doi:10.1046/j.1523-1747.1999.00524.x.
- ^ Schürer, N; Köhne, A; Schliep, V; Barlag, K; Goerz, G. Lipid composition and synthesis of HaCaT cells, an immortalized human keratinocyte line, in comparison with normal human adult keratinocytes.. Experimental dermatology. 1993-08, 2 (4): 179–85 [2019-11-28]. PMID 8162337. doi:10.1111/j.1600-0625.1993.tb00030.x.
- ^ Lehmann, B. HaCaT cell line as a model system for vitamin D3 metabolism in human skin.. The Journal of investigative dermatology. 1997-01, 108 (1): 78–82 [2019-11-28]. PMID 8980292. doi:10.1111/1523-1747.ep12285640.