迈耶斯合成
迈耶斯合成（英語：Meyers synthesis），得名於美国化学家艾伯特·I·迈耶斯，指通过噁嗪水解制取不对称醛类。[1][2][3][4]
2-取代的二氢-1,3-噁嗪的α-氢被强碱（如丁基锂）夺取，生成的碳负离子被卤代烃烷化，然后硼氢化钠将碳氮双键还原，最后在草酸水溶液中水解，半缩胺转变为醛。
参见
[编辑]参考资料
[编辑]- ^ Aldehydes from dihydro-1,3-oxazines. I. Synthesis of aliphatic aldehydes and their C-1 deuterated derivatives Albert I. Meyers, Aiko Nabeya, H. Wayne Adickes, Ieva R. Politzer J. Am. Chem. Soc. 1969; 91(3); 763-764. doi:10.1021/ja01031a053
- ^ Aldehydes from dihydro-1,3-oxazines. II. Synthesis of .alpha.,.beta.-unsaturated aldehydes and their C-1 deuterated derivatives Albert I. Meyers, Aiko Nabeya, H. Wayne Adickes, J. Michael Fitzpatrick, G. Ray Malone, and Ieva R. Politzer pp 764 - 765; J. Am. Chem. Soc. 1969 {{DOI:10.1021/ja01031a054}}
- ^ Aldehydes from dihydro-1,3-oxazines. III. Synthesis of cycloalkanecarboxaldehydes Albert I. Meyers, H. Wayne Adickes, Ieva R. Politzer, and Warren N. Beverung pp 765 - 767; J. Am. Chem. Soc. 1969 doi:10.1021/ja01031a055
- ^ Organic Syntheses, Coll. Vol. 6, p.905 (1988); Vol. 51, p.24 (1971). http://www.orgsynth.org/orgsyn/pdfs/CV6P0905.pdf （页面存档备份，存于互联网档案馆）